Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 55 Researches
7.9
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Mood Probiotic BlendLactobacillus acidophilusLactobacillus plantarumLactobacillus helveticus R0052Lactobacillus paracaseiLactobacillus caseiLactobacillus brevisLactobacillus rhamnosusLactobacillus bulgaricusLactobacillus gasseriLactobacillus salivariusTotal Lacto Cultures (45 Billion CFU)Bifidobacterium lactisBifidobacterium longum R0175Bifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (5 Billion CFU)
200 mg
+
Total Probiotic Cultures
50 Billion CFU¹
Stress Support BlendOrganic Ashwagandha (root), Blueberry (fruit)
350 mg
+
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
675 mg
+
Top Medical Research Studies
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
Most Useful Reviews
9
Increased immunity
31 people found this helpful
If it had more than five stars, I would award it. My husband has greatly benefited in terms of immunity. He suffered from weather changes and often fell ill, but after consistently taking this, he has improved significantly. This is his fourth reorder due to the substantial benefits he's experienced, with God's grace. If you appreciate my review, please like 🤍
Read More
9
Enhanced mood
21 people found this helpful
Today marks 11 days of use, and I feel optimistic about continuing. After finishing the first box, I noticed significant improvements in my mood, with panic attacks and depressive feelings easing. My outlook is now more positive, and I've become calmer. I've ordered a second box and plan to maintain this regimen for several months, with occasional breaks.
Read More
9
Stabilised mood
5 people found this helpful
Probiotics are excellent! This supplement is essential for my daily routine—it stabilises my mood, alleviates anxiety, and helps prevent depressive episodes. After replacing prescription antidepressants that had unwanted side effects, I found this combination to be equally effective. I have experienced a noticeable improvement in my energy and mood within just two weeks. I'm absolutely delighted with its performance.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 55 Researches
7.9
- All Researches
9
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Read More
9
Synbiotics improve rheumatoid arthritis symptoms
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased immunity
31 people found this helpful
If it had more than five stars, I would award it. My husband has greatly benefited in terms of immunity. He suffered from weather changes and often fell ill, but after consistently taking this, he has improved significantly. This is his fourth reorder due to the substantial benefits he's experienced, with God's grace. If you appreciate my review, please like 🤍
Read More
9
Enhanced mood
21 people found this helpful
Today marks 11 days of use, and I feel optimistic about continuing. After finishing the first box, I noticed significant improvements in my mood, with panic attacks and depressive feelings easing. My outlook is now more positive, and I've become calmer. I've ordered a second box and plan to maintain this regimen for several months, with occasional breaks.
Read More
9
Stabilised mood
5 people found this helpful
Probiotics are excellent! This supplement is essential for my daily routine—it stabilises my mood, alleviates anxiety, and helps prevent depressive episodes. After replacing prescription antidepressants that had unwanted side effects, I found this combination to be equally effective. I have experienced a noticeable improvement in my energy and mood within just two weeks. I'm absolutely delighted with its performance.
Read More
9
Improved mood
1 people found this helpful
Makes a difference! I ordered it for a friend suffering from depression, and she reports that it genuinely enhances her mood. She requested that I order it again for her.
Read More
9
Enhanced relaxation
1 people found this helpful
Initially sceptical, I bought this due to years of stomach issues affecting my mood. It genuinely enhances my mood and relaxation. I can hardly remember feeling as calm, and as always with Garden of Life products, it sorts out my stomach issues. Thanks, Iherb!
Read More
Frequently Asked Questions
9
Enhanced mood
21 people found this helpful
Today marks 11 days of use, and I feel optimistic about continuing. After finishing the first box, I noticed significant improvements in my mood, with panic attacks and depressive feelings easing. My outlook is now more positive, and I've become calmer. I've ordered a second box and plan to maintain this regimen for several months, with occasional breaks.
9
Stabilised mood
5 people found this helpful
Probiotics are excellent! This supplement is essential for my daily routine—it stabilises my mood, alleviates anxiety, and helps prevent depressive episodes. After replacing prescription antidepressants that had unwanted side effects, I found this combination to be equally effective. I have experienced a noticeable improvement in my energy and mood within just two weeks. I'm absolutely delighted with its performance.
7.5
Health difference
7 people found this helpful
A great mood booster! I hadn’t realised how effective this was until I ran out and delayed reordering. I felt a significant change in my overall feelings during that time. I will ensure I never run out again as it has made such a difference in my health.
9
Enhanced relaxation
1 people found this helpful
Initially sceptical, I bought this due to years of stomach issues affecting my mood. It genuinely enhances my mood and relaxation. I can hardly remember feeling as calm, and as always with Garden of Life products, it sorts out my stomach issues. Thanks, Iherb!
7.5
Gastrointestinal relief
Excellent! This high-quality product was recommended to me for women's gut health. After using it for a year, I switched to a probiotic for men, and my partner has ordered it multiple times. He noted improvements in gastrointestinal symptoms like gas and discomfort after meals. However, it’s tough to gauge its mood-boosting effects due to stress in his life. We're eager for it to be back in stock to purchase again!
9
Transformed mood
1 people found this helpful
I’ve tried numerous probiotics, but Garden of Life products are the best. This probiotic has remarkably enhanced my mood and well-being. I now wake up feeling happy, and my digestion has notably improved. I have noticed a significant decline in my mood when I was out of stock, hence I double my orders now.
7.5
Digestive help
1 people found this helpful
I order these probiotics for my husband, who states they help his digestion and mood significantly.
8
Lactic acid bacteria combat autoimmune symptoms
We investigated the potential of Lactobacillus and Bifidobacterium in alleviating symptoms of multiple sclerosis using a rat model. The study involved 48 male rats, which were divided into groups to evaluate the effects of these bacteria on demyelination caused by cuprizone.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
The results showed that treatment with lactic acid bacteria notably improved behavioral impairments, decreased demyelination, reduced oxidative stress, and elevated serum levels of vitamins D and B.
Overall, these findings indicate that Lactobacillus and Bifidobacterium may be beneficial in managing autoimmune conditions like multiple sclerosis.
8
This randomized, double-blind trial sought to see how synbiotics, including Lactobacillus acidophilus, could help patients with systemic lupus erythematosus (SLE). Fifty patients were divided into two groups: one received synbiotics alongside their standard therapy, while the other got standard therapy alone over two months.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
We observed that those who took the synbiotics showed a meaningful drop in inflammatory markers like interleukin-17A and overall disease activity. Meanwhile, the placebo group didn’t see these improvements. While these findings are promising, we recognize that more research is necessary to fully understand how synbiotics work in SLE management.
8
We explored the effects of Lactobacillus acidophilus and propionate on Sjögren's syndrome in a mouse model. Our study involved comparing the gut microbiomes of young and older mice while treating them for up to 24 weeks.
Notably, we observed that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome and led to an increase in beneficial propionate-producing bacteria. This treatment appears to work by modulating key signaling pathways involved in the condition.
Overall, our findings suggest that Lactobacillus acidophilus and propionate might offer promising therapeutic options for managing Sjögren's syndrome.
Notably, we observed that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome and led to an increase in beneficial propionate-producing bacteria. This treatment appears to work by modulating key signaling pathways involved in the condition.
Overall, our findings suggest that Lactobacillus acidophilus and propionate might offer promising therapeutic options for managing Sjögren's syndrome.
7
DHA may aid autoimmune management
We looked into how docosahexaenoic acid (DHA), an omega-3 fatty acid, plays a role in managing autoimmune disorders. Our focus was on its anti-inflammatory properties and their potential to reduce disease activity in conditions like rheumatoid arthritis, lupus, and multiple sclerosis.
DHA is known for its beneficial effects on the immune system. We found that it can help inhibit the release of pro-inflammatory cytokines and reduce the activity of immune cells that contribute to autoimmunity. This means that integrating DHA into our diets might be a helpful strategy for those dealing with autoimmune diseases.
Additionally, research indicates that DHA supplementation can lead to improvements in symptom severity and overall health outcomes in autoimmune patients. With no definitive cures available for these conditions, the anti-inflammatory effects of DHA present an exciting avenue for future exploration.
It's important to emphasize that while the evidence suggests significant benefits, further randomized clinical trials are necessary to establish the best doses and confirm these findings. However, the current data certainly supports considering DHA as part of our approach to managing autoimmune disorders.
DHA is known for its beneficial effects on the immune system. We found that it can help inhibit the release of pro-inflammatory cytokines and reduce the activity of immune cells that contribute to autoimmunity. This means that integrating DHA into our diets might be a helpful strategy for those dealing with autoimmune diseases.
Additionally, research indicates that DHA supplementation can lead to improvements in symptom severity and overall health outcomes in autoimmune patients. With no definitive cures available for these conditions, the anti-inflammatory effects of DHA present an exciting avenue for future exploration.
It's important to emphasize that while the evidence suggests significant benefits, further randomized clinical trials are necessary to establish the best doses and confirm these findings. However, the current data certainly supports considering DHA as part of our approach to managing autoimmune disorders.
7
We explored the impact of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, and etanercept, an anti-TNF therapy, on the symptoms of rheumatoid arthritis (RA) in a study involving rats. The aim was to see if combining these treatments could alleviate pain, improve mobility, and prevent metabolic issues commonly associated with RA. To do this, we induced collagen-induced arthritis (CIA) in rats and monitored their responses to the treatments.
Our findings revealed that while etanercept significantly reduced pain and improved the overall RA scoring index, DHA had a notable effect on body composition and helped mitigate some metabolic alterations. However, we did not find any substantial synergy between DHA and etanercept, indicating that while these treatments can individually offer benefits, they do not seem to work better together.
This study sheds light on the potential of DHA as a nutritional supplement for managing certain RA symptoms, especially in patients who may prefer to avoid additional pharmacological treatments. However, it’s clear that using DHA in conjunction with etanercept did not provide any additional advantages.
Our findings revealed that while etanercept significantly reduced pain and improved the overall RA scoring index, DHA had a notable effect on body composition and helped mitigate some metabolic alterations. However, we did not find any substantial synergy between DHA and etanercept, indicating that while these treatments can individually offer benefits, they do not seem to work better together.
This study sheds light on the potential of DHA as a nutritional supplement for managing certain RA symptoms, especially in patients who may prefer to avoid additional pharmacological treatments. However, it’s clear that using DHA in conjunction with etanercept did not provide any additional advantages.
References
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- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. doi:10.1111/1750-3841.17460
- Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, et al. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023;21:135. doi:10.1186/s12964-023-01141-0
- Kim DS, Park Y, Choi JW, Park SH, Cho ML, et al. Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice the SIGNR3 Pathway. Front Immunol. 2021;12:696074. doi:10.3389/fimmu.2021.696074
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- Kim TK, Lee JC, Im SH, Lee MS. Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics. Front Immunol. 2020;11:1832. doi:10.3389/fimmu.2020.01832
- Kamal Y, Kandil M, Eissa M, Yousef R, Elsaadany B. Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. Rheumatol Int. 2020;40:873. doi:10.1007/s00296-020-04558-9
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- Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117:1095. doi:10.1017/S000711451700085X
- Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. doi:10.1111/1756-185X.12888
- Bleau C, Lamontagne L, Savard R. New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol. 2005;140:427.
- Ahmadi P, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Ahmadi-Khorram M, et al. The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages. Food Sci Nutr. 2025;13:e70068. doi:10.1002/fsn3.70068
- Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. doi:10.1039/d4fo03966a
- Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. doi:10.1002/cbf.3981
- Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. doi:10.1007/s12010-023-04827-w
- Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. doi:10.1186/s13287-023-03578-z
- Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. doi:10.1016/j.imbio.2023.152415
- Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. doi:10.3389/fmed.2023.1085578
- Lin H, Lin J, Pan T, Li T, Jiang H, et al. Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023;14:68. doi:10.1038/s41419-023-05589-3
- Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. doi:10.32598/bcn.2021.1955.1
- Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. doi:10.3390/biology11111574
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. doi:10.1152/ajpgi.00072.2021
- Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. doi:10.1039/c9fo02556a
- Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. doi:10.1002/jcp.27663
- Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. doi:10.1002/jcp.26819
- Piva F, Gervois P, Karrout Y, Sané F, Romond MB. Gut-Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development. Nutrients. 2023;15. doi:10.3390/nu15234861
- Huo D, Cen C, Chang H, Ou Q, Jiang S, et al. Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis. Commun Biol. 2021;4:1046. doi:10.1038/s42003-021-02587-z
- Li D, Cheng J, Zhu Z, Catalfamo M, Goerlitz D, et al. Treg-inducing capacity of genomic DNA of subsp. . Allergy Asthma Proc. 2020;41:372. doi:10.2500/aap.2020.41.200064
- Shi P, Qu H, Nian D, Chen Y, Liu X, et al. Treatment of Guillain-Barré syndrome with Bifidobacterium infantis through regulation of T helper cells subsets. Int Immunopharmacol. 2018;61:290. doi:10.1016/j.intimp.2018.06.015
- Laparra JM, Olivares M, Sanz Y. Oral administration of Bifidobacterium longum CECT 7347 ameliorates gliadin-induced alterations in liver iron mobilisation. Br J Nutr. 2013;110:1828. doi:10.1017/S0007114513001098
- Laparra JM, Olivares M, Gallina O, Sanz Y. Bifidobacterium longum CECT 7347 modulates immune responses in a gliadin-induced enteropathy animal model. PLoS One. 2012;7:e30744. doi:10.1371/journal.pone.0030744
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. doi:10.3389/fimmu.2025.1518181
- Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. doi:10.3389/fendo.2022.754401
- Zhang H, Liu M, Liu X, Zhong W, Li Y, et al. ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells. Front Immunol. 2020;11:569104. doi:10.3389/fimmu.2020.569104
- Cardoso RS, Messora MR, Silva PHF, Oliveira LF, Leite-Panissi C, et al. Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. Benef Microbes. 2020;11:33. doi:10.3920/BM2019.0038
- Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. doi:10.1016/j.biopha.2017.08.117
- Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. doi:10.1111/j.1365-2249.2008.03788.x
- Gilley KN, Fenton JI, Zick SM, Li K, Wang L, et al. Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program. Front Immunol. 2024;15:1459297. doi:10.3389/fimmu.2024.1459297
- Szczuko M, Kacprzak J, Przybylska A, Szczuko U, Pobłocki J, et al. The Influence of an Anti-Inflammatory Gluten-Free Diet with EPA and DHA on the Involvement of Maresin and Resolvins in Hashimoto's Disease. Int J Mol Sci. 2024;25. doi:10.3390/ijms252111692
- Su Y, Han Y, Choi HS, Lee GY, Cho HW, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis. Biomed Pharmacother. 2024;171:116153. doi:10.1016/j.biopha.2024.116153
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